resize in bitmap vs resize in multi layer viewer

Hi,

We would like to check..
let say, we would like to print an image which is 2" x 3"... (render @ 300dpi)

And we have bigger image (let say 4" x 6" for 300dpi)..

If we want the output quality to be as close as the original..

Shall we resize it, then only add into ImageVObject ?
Or, we should put the original image into ImageVObject and resize the VObject? What our concern is, when we resize it outside, it will be scaled to the scrren res (96 dpi) and affect the final output?